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| Molecular Profile | BRAF mutant |
| Therapy | Selumetinib |
| Indication/Tumor Type | thyroid cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF mutant | thyroid cancer | predicted - sensitive | Selumetinib | Phase I | Actionable | In a Phase I study, Koselugo (selumetinib) demonstrated an increase in iodine uptake and retention in a subgroup of patients with thyroid cancer that was refractory to radioiodine, including patients with BRAF and NRAS mutations (PMID: 23406027). | 23406027 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (23406027) | Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer. | Full reference... |