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Molecular Profile | CD274 positive |
Therapy | SL-279252 |
Indication/Tumor Type | lung non-small cell carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CD274 positive | lung non-small cell carcinoma | sensitive | SL-279252 | Preclinical - Cell culture | Actionable | In a preclinical study, SL-279252 treatment coupled the activation of T-lymphocytes with induction of tumor cell apoptosis in a coculture of CD274-positive non-small cell lung cancer cells and CD3-positive T-lymphocytes (PMID: 30563566). | 30563566 |
PubMed Id | Reference Title | Details |
---|---|---|
(30563566) | Agonist redirected checkpoint, PD1-Fc-OX40L, for cancer immunotherapy. | Full reference... |