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| Molecular Profile | CDKN2A loss |
| Therapy | GSK461364 + Palbociclib |
| Indication/Tumor Type | pancreatic cancer |
| Response Type | decreased response |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CDKN2A loss | pancreatic cancer | decreased response | GSK461364 + Palbociclib | Preclinical | Actionable | In a preclinical study, Ibrance (palbociclib) antagonized the efficacy of GSK461364 in pancreatic cancer cells with CDKN2A loss in culture (PMID: 25156567). | 25156567 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (25156567) | CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer. | Full reference... |