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Molecular Profile | BRAF K601E |
Therapy | Trametinib |
Indication/Tumor Type | pancreatic endocrine carcinoma |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF K601E | pancreatic endocrine carcinoma | predicted - resistant | Trametinib | Case Reports/Case Series | Actionable | In a clinical case study, a patient with a pancreatic neuroendocrine tumor harboring BRAF K601E demonstrated progressive disease when treated with Mekinist (trametinib) (PMID: 31158244). | 31158244 |
PubMed Id | Reference Title | Details |
---|---|---|
(31158244) | Rare BRAF mutations in pancreatic neuroendocrine tumors may predict response to RAF and MEK inhibition. | Full reference... |