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Molecular Profile | BRAF V600E |
Therapy | Vemurafenib |
Indication/Tumor Type | pancreatic endocrine carcinoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | pancreatic endocrine carcinoma | predicted - sensitive | Vemurafenib | Case Reports/Case Series | Actionable | In a clinical case study, a patient with pancreatic endocrine carcinoma found to harbor BRAF V600E demonstrated stable disease and some tumor shrinkage when treated with Zelboraf (vemurafenib) (PMID: 31158244). | 31158244 |
PubMed Id | Reference Title | Details |
---|---|---|
(31158244) | Rare BRAF mutations in pancreatic neuroendocrine tumors may predict response to RAF and MEK inhibition. | Full reference... |