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Molecular Profile | EML4 - ALK ALK L1256F |
Therapy | Lorlatinib |
Indication/Tumor Type | lung adenocarcinoma |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
EML4 - ALK ALK L1256F | lung adenocarcinoma | resistant | Lorlatinib | Preclinical - Cell culture | Actionable | In a preclinical study, Lorbrena (lorlatinib) did not inhibit Alk kinase activity or proliferation of lung adenocarcinoma cells expressing ALK L1256F in the context of EML4-ALK in cell culture (PMID: 30662002). | 30662002 |
PubMed Id | Reference Title | Details |
---|---|---|
(30662002) | Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance. | Full reference... |