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| Molecular Profile | KIT M541L |
| Therapy | Imatinib |
| Indication/Tumor Type | chronic leukemia |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT M541L | chronic leukemia | sensitive | Imatinib | Phase I | Actionable | In Phase I trials, KIT M541L has been associated with response to Gleevec (imatinib) in chronic eosinophilic leukemia, NOS (PMID: 25015329) and mastocytosis (PMID: 18795925). | 25015329 18795925 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (18795925) | Association of paediatric mastocytosis with a polymorphism resulting in an amino acid substitution (M541L) in the transmembrane domain of c-KIT. | Full reference... |
| (25015329) | Identification of kit(M541L) somatic mutation in chronic eosinophilic leukemia, not otherwise specified and its implication in low-dose imatinib response. | Full reference... |