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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BTK T316A | lymphoma | resistant | Ibrutinib | Preclinical - Cell culture | Actionable | In a preclinical study, lymphoma cells expressing BTK T316A were resistant to Imbruvica (ibrutinib) in culture (PMID: 27626698) | 27626698 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27626698) | Identification of a structurally novel BTK mutation that drives ibrutinib resistance in CLL. | Full reference... |