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| Molecular Profile | APC E582fs |
| Therapy | G007-LK |
| Indication/Tumor Type | colorectal cancer |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| APC E582fs | colorectal cancer | predicted - resistant | G007-LK | Preclinical | Actionable | In a preclinical study, G007-LK treatment did not inhibit growth of mouse intestinal organoids expressing APC E580fs (corresponding to E582fs in human) in culture (PMID: 31337618). | 31337618 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (31337618) | Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition. | Full reference... |