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| Molecular Profile | APC Q886* |
| Therapy | NVP-TNKS656 |
| Indication/Tumor Type | colorectal cancer |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| APC Q886* | colorectal cancer | predicted - resistant | NVP-TNKS656 | Preclinical | Actionable | In a preclinical study, NVP-TNKS656 treatment did not affect growth of mouse intestinal organoids expressing APC Q884* (corresponding to Q886* in human) in culture (PMID: 31337618). | 31337618 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (31337618) | Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition. | Full reference... |