Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Molecular Profile | VHL negative |
| Therapy | STF-62247 |
| Indication/Tumor Type | renal cell carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| VHL negative | renal cell carcinoma | sensitive | STF-62247 | Preclinical | Actionable | In a preclinical study, STF-62247 induced selective cytotoxicity and inhibited tumor growth of renal cell carcinoma cells lacking VHL (PMID: 18769110, PMID: 18598947). | 18769110 18598947 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (18769110) | Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death. | Full reference... |
| (18598947) | A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. | Full reference... |