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| Molecular Profile | TP53 wild-type |
| Therapy | Adavosertib + PF-00477736 |
| Indication/Tumor Type | colon cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 wild-type | colon cancer | sensitive | Adavosertib + PF-00477736 | Preclinical | Actionable | In a preclinical study, Adavosertib (MK-1775), in combination with the Chk1 inhibitor, PF-00477736, showed efficacy in various human cancer cell lines (breast, ovarian, colon, prostate), independently of p53 status (PMID: 22713237). | 22713237 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (22713237) | Combined inhibition of Chk1 and Wee1: in vitro synergistic effect translates to tumor growth inhibition in vivo. | Full reference... |