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| Molecular Profile | IDH2 R140Q |
| Therapy | AGI-6780 |
| Indication/Tumor Type | acute myeloid leukemia |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| IDH2 R140Q | acute myeloid leukemia | sensitive | AGI-6780 | Preclinical | Actionable | In a preclinical study, treatment with AGI-6780 resulted in the differentiation of erythroleukemia and AML cell lines expressing IDH2 R140Q (PMID: 23558173). | 23558173 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (23558173) | Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. | Full reference... |