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Molecular Profile | FLT3 exon 14 ins FLT3 LOH |
Therapy | FLT3/CD3 Fabsc antibody + Quizartinib |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 exon 14 ins FLT3 LOH | acute myeloid leukemia | sensitive | FLT3/CD3 Fabsc antibody + Quizartinib | Preclinical - Cell culture | Actionable | In a preclinical study, treatment with the combination of Vanflyta (quizartinib) and an Fabsc FLT3/CD3 bi-specific antibody resulted in increased cytotoxicity over either agent alone in an acute myeloid leukemia cell line and patient-derived xenograft (PDX)-derived AML cells with a FLT3-ITD mutation and FLT3 loss of heterozygosity, leading to near complete eradication of AML cells in culture (PMID: 28895560). | 28895560 |
PubMed Id | Reference Title | Details |
---|---|---|
(28895560) | Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia. | Full reference... |