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Molecular Profile | CSF3R T618I |
Therapy | Dasatinib |
Indication/Tumor Type | hematologic cancer |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CSF3R T618I | hematologic cancer | predicted - resistant | Dasatinib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed hematologic cells expressing CSF3R T618I demonstrated resistance to treatment with Sprycel (dasatinib) in culture (PMID: 28031554). | 28031554 |
PubMed Id | Reference Title | Details |
---|---|---|
(28031554) | Enhanced MAPK signaling is essential for CSF3R-induced leukemia. | Full reference... |