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Molecular Profile | CSF3R S783fs |
Therapy | Tofacitinib |
Indication/Tumor Type | chronic neutrophilic leukemia |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CSF3R S783fs | chronic neutrophilic leukemia | predicted - resistant | Tofacitinib | Preclinical - Patient cell culture | Actionable | In a preclinical study, cells derived from a patient with chronic neutrophilic leukemia harboring CSF3R S783fs did not respond to treatment with Xeljanz (tofacitinib) in culture (PMID: 23656643). | 23656643 |
PubMed Id | Reference Title | Details |
---|---|---|
(23656643) | Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. | Full reference... |