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Molecular Profile | FGFR2 amp |
Therapy | Zotatifin |
Indication/Tumor Type | colorectal cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR2 amp | colorectal cancer | sensitive | Zotatifin | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Zotatifin (eFT226) inhibited cell growth, and induced apoptosis in a FGFR2-amplified colorectal cancer cell line in culture, and inhibited tumor growth, and induced regression in a cell line xenograft model (Mol Cancer Ther 2019;18(12 Suppl):Abstract nr B133). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
eFT226, a first in class inhibitor of eIF4A1, targets FGFR1/2 and HER2 driven cancers | Full reference... |