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Molecular Profile | JAK1 R724S |
Therapy | Ruxolitinib |
Indication/Tumor Type | cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
JAK1 R724S | cancer | sensitive | Ruxolitinib | Preclinical | Actionable | In a preclinical study, transformed cells harboring JAK1 R724S were sensitive to ATP-competetive JAK inhibitors, such as Jakafi (Ruxolitinib) (PMID: 21393331). | 21393331 |
PubMed Id | Reference Title | Details |
---|---|---|
(21393331) | Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors. | Full reference... |