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| Molecular Profile | JAK2 V617F JAK2 R971G |
| Therapy | Ruxolitinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| JAK2 V617F JAK2 R971G | Advanced Solid Tumor | resistant | Ruxolitinib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed cells expressing JAK2 V617F and R971G demonstrated resistance to Jakafi (Ruxolitinib) in culture (PMID: 26419724). | 26419724 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26419724) | Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance. | Full reference... |