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Molecular Profile | TP53 R175P |
Therapy | Doxorubicin + Nutlin-3a |
Indication/Tumor Type | lung adenocarcinoma |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 R175P | lung adenocarcinoma | no benefit | Doxorubicin + Nutlin-3a | Preclinical - Cell culture | Actionable | In a preclinical study, Nutlin-3 and Adriamycin (doxorubicin) combination treatment did not induce apoptosis in a lung adenocarcinoma cell line expressing TP53 R175P in culture (PMID: 31483066). | 31483066 |
PubMed Id | Reference Title | Details |
---|---|---|
(31483066) | Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses. | Full reference... |