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| Molecular Profile | TP53 R181E |
| Therapy | Doxorubicin + Nutlin-3a |
| Indication/Tumor Type | lung adenocarcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 R181E | lung adenocarcinoma | sensitive | Doxorubicin + Nutlin-3a | Preclinical - Cell culture | Actionable | In a preclinical study, a lung adenocarcinoma cell line expressing TP53 R181E demonstrated enhanced sensitivity to Adriamycin (doxorubicin) treatment when combined with Nutlin-3, and induced apoptosis in culture (PMID: 31483066). | 31483066 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (31483066) | Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses. | Full reference... |