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Molecular Profile | JAK2 V617F JAK2 Y931C JAK2 S1025C |
Therapy | Fedratinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
JAK2 V617F JAK2 Y931C JAK2 S1025C | Advanced Solid Tumor | resistant | Fedratinib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed cells expressing JAK2 V617F, Y931C and S1025C demonstrated resistance to Inrebic (fedratinib) treatment in culture (PMID: 26419724). | 26419724 |
PubMed Id | Reference Title | Details |
---|---|---|
(26419724) | Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance. | Full reference... |