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Molecular Profile JAK2 V617F JAK2 Y931C JAK2 F1061W
Therapy Fedratinib
Indication/Tumor Type Advanced Solid Tumor
Response Type resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
JAK2 V617F JAK2 Y931C JAK2 F1061W Advanced Solid Tumor resistant Fedratinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing JAK2 V617F, Y931C and F1061W demonstrated resistance to Inrebic (fedratinib) treatment in culture (PMID: 26419724). 26419724
PubMed Id Reference Title Details
(26419724) Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance. Full reference...