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| Molecular Profile | KDR wild-type |
| Therapy | Ramucirumab |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KDR wild-type | Advanced Solid Tumor | predicted - sensitive | Ramucirumab | Phase I | Actionable | In a Phase I trial, Cyramza (ramucirumab), an inhibitor of KDR (VEGFR2), demonstrated safety and efficacy (partial response or stable disease) in patients with advanced solid tumors (PMID: 20048182). | 20048182 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (20048182) | Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2. | Full reference... |