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| Molecular Profile | FLT3 E598_Y599insFDFREYE FLT3 R845G |
| Therapy | Quizartinib |
| Indication/Tumor Type | B-cell adult acute lymphocytic leukemia |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 E598_Y599insFDFREYE FLT3 R845G | B-cell adult acute lymphocytic leukemia | sensitive | Quizartinib | Preclinical - Cell culture | Actionable | In a preclinical study, B-cell acute lymphocytic leukemia cells harboring FLT3 R845G and FLT3 E598_Y599insFDFREYE were sensitive to treatment with Vanflyta (quizartinib), demonstrating decreased cell viability in culture (PMID: 30962949). | 30962949 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (30962949) | Glucocorticoid-resistant B cell acute lymphoblastic leukemia displays receptor tyrosine kinase activation. | Full reference... |