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| Molecular Profile | PTEN negative |
| Therapy | Niraparib |
| Indication/Tumor Type | prostate cancer |
| Response Type | not predictive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PTEN negative | prostate cancer | not predictive | Niraparib | Phase I | Actionable | In a Phase I trial, negative PTEN IHC staining was not associated with response to Zejula (niraparib) treatment in patients with castration-resistant prostate cancer (PMID: 23810788; NCT00749502). | 23810788 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (23810788) | The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial. | Full reference... |