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Molecular Profile | PTEN negative |
Therapy | Niraparib |
Indication/Tumor Type | prostate cancer |
Response Type | not predictive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PTEN negative | prostate cancer | not predictive | Niraparib | Phase I | Actionable | In a Phase I trial, negative PTEN IHC staining was not associated with response to Zejula (niraparib) treatment in patients with castration-resistant prostate cancer (PMID: 23810788; NCT00749502). | 23810788 |
PubMed Id | Reference Title | Details |
---|---|---|
(23810788) | The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial. | Full reference... |