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Molecular Profile CBL Y371del FLT3 pos
Therapy Gilteritinib
Indication/Tumor Type hematologic cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CBL Y371del FLT3 pos hematologic cancer sensitive Gilteritinib Preclinical - Cell culture Actionable In a preclinical study, Xospata (gilteritinib) inhibited proliferation of cells expressing wild-type FLT3 and CBL Y371del in culture (PMID: 31943762). 31943762
PubMed Id Reference Title Details
(31943762) The combination of FLT3 and SYK kinase inhibitors is toxic to leukaemia cells with CBL mutations. Full reference...