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Molecular Profile | CBL Y371H FLT3 pos |
Therapy | Midostaurin + PRT062607 |
Indication/Tumor Type | hematologic cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CBL Y371H FLT3 pos | hematologic cancer | sensitive | Midostaurin + PRT062607 | Preclinical - Cell culture | Actionable | In a preclinical study, the addition of PRT062607 to treatment with Rydapt (midostaurin) resulted in enhanced inhibition of proliferation of cells expressing wild-type FLT3 and CBL Y371H in culture (PMID: 31943762). | 31943762 |
PubMed Id | Reference Title | Details |
---|---|---|
(31943762) | The combination of FLT3 and SYK kinase inhibitors is toxic to leukaemia cells with CBL mutations. | Full reference... |