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Molecular Profile | PIK3CA E542K |
Therapy | PD-0325901 + Pictilisib |
Indication/Tumor Type | colorectal cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA E542K | colorectal cancer | sensitive | PD-0325901 + Pictilisib | Preclinical - Cell line xenograft | Actionable | In preclinical studies, the combination of GDC-0941 and PD-0325901 (PI3K and MEK inhibitors, respectively) inhibited tumor growth in colorectal cancer cell line xenograft models (PMID: 24339963). | 24339963 |
PubMed Id | Reference Title | Details |
---|---|---|
(24339963) | The enhanced in vivo activity of the combination of a MEK and a PI3K inhibitor correlates with [18F]-FLT PET in human colorectal cancer xenograft tumour-bearing mice. | Full reference... |