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| Molecular Profile | BRAF V600E |
| Therapy | Trametinib |
| Indication/Tumor Type | colorectal cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V600E | colorectal cancer | sensitive | Trametinib | Preclinical | Actionable | In a preclinical study, colorectal cancer cells harboring a BRAF V600E mutation had increased sensitivity to Mekinist (trametinib) compared to other colorectal cancer lines in culture (PMID: 25309914). | 25309914 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (25309914) | Biological and molecular effects of small molecule kinase inhibitors on low-passage human colorectal cancer cell lines. | Full reference... |