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| Molecular Profile | PDGFRB rearrange |
| Therapy | Imatinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PDGFRB rearrange | Advanced Solid Tumor | predicted - sensitive | Imatinib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed cells expressing a PDGFRB rearrangement were sensitive to treatment with Gleevec (imatinib), demonstrating decreased colony formation and reduced cell growth in culture (PMID: 31645346). | 31645346 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (31645346) | Novel PDGFRB rearrangement in multifocal infantile myofibromatosis is tumorigenic and sensitive to imatinib. | Full reference... |