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| Molecular Profile | PIK3CA E545K |
| Therapy | Capivasertib |
| Indication/Tumor Type | stomach cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA E545K | stomach cancer | sensitive | Capivasertib | Preclinical - Cell culture | Actionable | In a preclinical study, a gastric cancer cell line harboring PIK3CA E545K was sensitive to treatment with Truqap (capivasertib), demonstrating decreased cell proliferation in culture (PMID: 32070411). | 32070411 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (32070411) | Comprehensive pharmacogenomic characterization of gastric cancer. | Full reference... |