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Molecular Profile | PIK3CA E542K |
Therapy | Capivasertib |
Indication/Tumor Type | stomach cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA E542K | stomach cancer | sensitive | Capivasertib | Case Reports/Case Series | Actionable | In a clinical case study, treatment with Truqap (capivasertib) in a patient with gastric cancer harboring PIK3CA E542K resulted in a partial response, and in preclinical studies, led to decreased cell proliferation in a gastric cancer cell line harboring PIK3CA E542K (PMID: 32070411). | 32070411 |
PubMed Id | Reference Title | Details |
---|---|---|
(32070411) | Comprehensive pharmacogenomic characterization of gastric cancer. | Full reference... |