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| Molecular Profile | FGFR2 amp |
| Therapy | Regorafenib |
| Indication/Tumor Type | colorectal cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR2 amp | colorectal cancer | predicted - sensitive | Regorafenib | Preclinical - Cell culture | Actionable | In a preclinical study, a colorectal cancer cell line with FGFR1 and FGFR2 amplification was sensitive to treatment with Stivarga (regorafenib), demonstrating inhibition of cell growth in culture (PMID: 33563752). | 33563752 |
| FGFR2 amp | colorectal cancer | predicted - sensitive | Regorafenib | Preclinical - Cell culture | Actionable | In a preclinical study, Stivarga (regorafenib) inhibited Fgfr2 signaling and proliferation of FGFR2-amplified colorectal cancer cells in culture (PMID: 29573334). | 29573334 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (29573334) | FGFR2 amplification is predictive of sensitivity to regorafenib in gastric and colorectal cancers in vitro. | Full reference... |
| (33563752) | Rapid Resistance of FGFR-driven Gastric Cancers to Regorafenib and Targeted FGFR Inhibitors can be Overcome by Parallel Inhibition of MEK. | Full reference... |