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| Molecular Profile | STK11 Y253* STK11 dec exp |
| Therapy | Sirolimus |
| Indication/Tumor Type | stomach carcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| STK11 Y253* STK11 dec exp | stomach carcinoma | predicted - sensitive | Sirolimus | Preclinical - Cell culture | Actionable | In a preclinical study, Rapamune (sirolimus) suppressed the growth of gastric carcinoma cells harboring STK11 Y253* with decreased Stk11 protein expression in culture (PMID: 32236518). | 32236518 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (32236518) | Serine threonine kinase 11/liver kinase B1 mutation in sporadic scirrhous-type gastric cancer cells. | Full reference... |