Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Molecular Profile | BTK C481S |
| Therapy | Venetoclax |
| Indication/Tumor Type | chronic lymphocytic leukemia |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BTK C481S | chronic lymphocytic leukemia | predicted - resistant | Venetoclax | Case Reports/Case Series | Actionable | In a clinical case study, a patient with chronic lymphocytic leukemia who had relapsed on treatment with Imbruvica (ibrutinib) was treated with Venclexta (venetoclax), but progressed and was found to harbor BTK C481S (PMID: 32232486). | 32232486 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (32232486) | Novel BCL2 mutations in venetoclax-resistant, ibrutinib-resistant CLL patients with BTK/PLCG2 mutations. | Full reference... |