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| Molecular Profile | PIK3CA R38C |
| Therapy | Sulindac |
| Indication/Tumor Type | head and neck squamous cell carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA R38C | head and neck squamous cell carcinoma | sensitive | Sulindac | Preclinical - Pdx | Actionable | In a preclinical study, Clinoril (sulindac) treatment reduced tumor growth rate in patient-derived xenograft (PDX) models of head and neck squamous cell carcinoma harboring PIK3CA mutations, including PIK3CA R38C (PMID: 30683736). | 30683736 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (30683736) | Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer. | Full reference... |