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Molecular Profile | FLT3 exon 14 ins FLT3 E654D |
Therapy | Olverembatinib |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 exon 14 ins FLT3 E654D | acute myeloid leukemia | predicted - sensitive | Olverembatinib | Preclinical - Patient cell culture | Actionable | In a preclinical study, Olverembatinib (HQP1351) reduced Flt3 and Stat5 activation and inhibited growth of patient-derived acute myeloid leukemia cells harboring FLT3-ITD and FLT3 E654D in culture (PMID: 32247263). | 32247263 |
PubMed Id | Reference Title | Details |
---|---|---|
(32247263) | GZD824 as a FLT3, FGFR1 and PDGFRα Inhibitor Against Leukemia In Vitro and In Vivo. | Full reference... |