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| Molecular Profile | PIK3CA E545K |
| Therapy | Dactolisib |
| Indication/Tumor Type | colorectal cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA E545K | colorectal cancer | sensitive | Dactolisib | Preclinical | Actionable | In a preclinical study, BEZ235 decreased cell proliferation in colorectal cancer cells harboring a PIK3CA E545K mutation in cell culture (PMID: 21966435). | 21966435 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (21966435) | The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer. | Full reference... |