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| Molecular Profile | PIK3CA act mut |
| Therapy | Afuresertib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA act mut | Advanced Solid Tumor | sensitive | Afuresertib | Preclinical | Actionable | In a preclinical study, various tumor cell lines harboring PI3KCA activating mutations demonstrated increased sensitivity to Afuresertib (GSK2110183) in cultured cells (PMID: 24978597). | 24978597 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (24978597) | Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor. | Full reference... |