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| Molecular Profile | PIK3CA H1047R |
| Therapy | Palbociclib |
| Indication/Tumor Type | oral squamous cell carcinoma |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA H1047R | oral squamous cell carcinoma | resistant | Palbociclib | Preclinical - Cell culture | Actionable | In a preclinical study, oral squamous cell carcinoma cells expressing PIK3CA H1047R demonstrated resistance to Ibrance (palbociclib) treatment in culture (PMID: 31516747). | 31516747 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (31516747) | Effects of palbociclib on oral squamous cell carcinoma and the role of PIK3CA in conferring resistance. | Full reference... |