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| Molecular Profile | ALK R1275Q |
| Therapy | Belizatinib |
| Indication/Tumor Type | neuroblastoma |
| Response Type | no benefit |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ALK R1275Q | neuroblastoma | no benefit | Belizatinib | Case Reports/Case Series | Actionable | In a Phase I trial, a neuroblastoma patient harboring ALK R1275Q did not respond to treatment with Belizatinib (TSR-011) (PMID: 31217479; NCT02048488). | 31217479 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (31217479) | A phase 1, open-label, dose-escalation trial of oral TSR-011 in patients with advanced solid tumours and lymphomas. | Full reference... |