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Molecular Profile | FGFR2 K310R FGFR2 N550K |
Therapy | Infigratinib + Navitoclax |
Indication/Tumor Type | endometrial cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR2 K310R FGFR2 N550K | endometrial cancer | sensitive | Infigratinib + Navitoclax | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Truseltiq (infigratinib) and Navitoclax (ABT-263) combination treatment enhanced apoptosis, and inhibited tumor growth and induced regression in a cell line xenograft model of endometrial cancer harboring FGFR2 K310R and N550K compared to either agent alone (PMID: 30537101). | 30537101 |
PubMed Id | Reference Title | Details |
---|---|---|
(30537101) | Bcl-2 inhibitors enhance FGFR inhibitor-induced mitochondrial-dependent cell death in FGFR2-mutant endometrial cancer. | Full reference... |