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Molecular Profile | FGFR3 S756P |
Therapy | Fexagratinib |
Indication/Tumor Type | lung non-small cell carcinoma |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR3 S756P | lung non-small cell carcinoma | no benefit | Fexagratinib | Case Reports/Case Series | Actionable | In a Phase II trial (NLMT), AZD4547 treatment did not result in a confirmed response or durable clinical benefit in a patient with non-small cell lung cancer harboring FGFR3 S758P (corresponds to S756P in the canonical isoform (PMID: 32669708, NCT02664935). | 32669708 |
PubMed Id | Reference Title | Details |
---|---|---|
(32669708) | The National Lung Matrix Trial of personalized therapy in lung cancer. | Full reference... |