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Molecular Profile | KIT C809G |
Therapy | Imatinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT C809G | Advanced Solid Tumor | predicted - resistant | Imatinib | Preclinical - Cell culture | Actionable | In a preclinical study, KIT C809G was resistant to inhibition of phosphorylation by Gleevec (imatinib) in cultured cells (PMID: 16954519). | 16954519 |
PubMed Id | Reference Title | Details |
---|---|---|
(16954519) | Molecular correlates of imatinib resistance in gastrointestinal stromal tumors. | Full reference... |