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Molecular Profile | FLT3 exon 14 ins FLT3 F621L |
Therapy | KW-2449 |
Indication/Tumor Type | hematologic cancer |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 exon 14 ins FLT3 F621L | hematologic cancer | resistant | KW-2449 | Preclinical - Cell culture | Actionable | In a preclinical study, transformed hematologic cells co-expressing FLT3 ITD and FLT3 F621L were resistant to treatment with KW-2449 in culture (PMID: 22858906). | 22858906 |
PubMed Id | Reference Title | Details |
---|---|---|
(22858906) | Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors. | Full reference... |