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| Molecular Profile | FLT3 exon 14 ins |
| Therapy | KW-2449 |
| Indication/Tumor Type | hematologic cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 exon 14 ins | hematologic cancer | sensitive | KW-2449 | Preclinical - Cell culture | Actionable | In a preclinical study, transformed hematologic cells expressing FLT3-ITD were sensitive to treatment with KW-2449, demonstrating growth inhibition in culture (PMID: 22858906). | 22858906 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (22858906) | Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors. | Full reference... |