Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Molecular Profile | PIK3CA E545K |
| Therapy | Ipatasertib + Paclitaxel |
| Indication/Tumor Type | breast cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA E545K | breast cancer | sensitive | Ipatasertib + Paclitaxel | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the combination of Ipatasertib (GDC-0068) and Taxol (paclitaxel) inhibited tumor growth in a cell line xenograft model of hormone-receptor positive breast cancer harboring PIK3CA E545K, and demonstrated increased activity over either agent alone (PMID: 32205017). | 32205017 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (32205017) | Antitumor activity of ipatasertib combined with chemotherapy: results from a phase Ib study in solid tumors. | Full reference... |