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Molecular Profile | PIK3CA E545K |
Therapy | Ipatasertib + Paclitaxel |
Indication/Tumor Type | breast cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA E545K | breast cancer | sensitive | Ipatasertib + Paclitaxel | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the combination of Ipatasertib (GDC-0068) and Taxol (paclitaxel) inhibited tumor growth in a cell line xenograft model of hormone-receptor positive breast cancer harboring PIK3CA E545K, and demonstrated increased activity over either agent alone (PMID: 32205017). | 32205017 |
PubMed Id | Reference Title | Details |
---|---|---|
(32205017) | Antitumor activity of ipatasertib combined with chemotherapy: results from a phase Ib study in solid tumors. | Full reference... |