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Molecular Profile PIK3CA F977Y
Therapy Pictilisib
Indication/Tumor Type head and neck squamous cell carcinoma
Response Type resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA F977Y head and neck squamous cell carcinoma resistant Pictilisib Preclinical - Cell culture Actionable In a preclinical study, a head and neck squamous cell carcinoma cell line harboring PIK3CA F977Y demonstrated resistance to growth inhibition by Pictilisib (GDC-0941) in culture (PMID: 30108165). 30108165
PubMed Id Reference Title Details
(30108165) Comprehensive Genomic Profiling of Patient-matched Head and Neck Cancer Cells: A Preclinical Pipeline for Metastatic and Recurrent Disease. Full reference...