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Molecular Profile EML4 - ALK
Therapy Alvocidib + Crizotinib
Indication/Tumor Type lung adenocarcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
EML4 - ALK lung adenocarcinoma predicted - sensitive Alvocidib + Crizotinib Preclinical - Cell culture Actionable In a preclinical study, Alvocidib (flavopiridol) treatment in combination with Xalkori (crizotinib) reduced viability of Xalkori (crizotinib)-resistant lung adenocarcinoma cells harboring EML4-ALK in culture, but did not result in synergistic effects (PMID: 32558295). 32558295
PubMed Id Reference Title Details
(32558295) Vulnerability of drug-resistant EML4-ALK rearranged lung cancer to transcriptional inhibition. Full reference...